Thymidine phosphorylase mRNA expression may be a predictor of response to post-operative adjuvant chemotherapy with S-1 in patients with stage III colorectal cancer

@inproceedings{Ogawa2014ThymidinePM,
  title={Thymidine phosphorylase mRNA expression may be a predictor of response to post-operative adjuvant chemotherapy with S-1 in patients with stage III colorectal cancer},
  author={Masaichi Ogawa and Michiaki Watanabe and Yoshinobu Mitsuyama and Tadashi Anan and Masahisa Ohkuma and Tetsuya J. Kobayashi and Ken Eto and Katsuhiko Yanaga},
  booktitle={Oncology letters},
  year={2014}
}
The aim of the present study was to investigate markers in surgically resected specimens of colorectal cancer that can be used to predict the response to chemotherapy. The mRNA expression levels of enzymes involved in 5-fluorouracil (5-FU) metabolism and folate metabolism were measured in formalin-fixed, paraffin-embedded tumor sections obtained from the primary tumors of 54 patients with resected stage II or III colorectal cancer who received S-1 for one year. The 5-FU metabolizing enzymes… CONTINUE READING

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