Thymidine phosphorylase expression is associated with time to progression in patients with metastatic colorectal cancer

@inproceedings{Lindskog2014ThymidinePE,
  title={Thymidine phosphorylase expression is associated with time to progression in patients with metastatic colorectal cancer},
  author={Elinor Bexe Lindskog and Kristoffer Derwinger and B Essen Gustavsson and Peter Falk and Yvonne Wettergren},
  booktitle={BMC clinical pathology},
  year={2014}
}
BACKGROUND 5-Fluorouracil (5-FU) is the cornerstone of chemotherapeutic treatment for patients with colorectal cancer. The enzyme thymidine phosphorylase (TP) catalyzes the conversion of 5-FU to its active metabolite, 5-fluoro-2'-deoxyuridine. TP is expressed in tumour epithelial cells and stromal cells, particularly in tumour-associated macrophages. These macrophages may affect sensitivity to chemotherapy. Previously, we identified TP as a predictive factor in microdissected tumour samples of… CONTINUE READING