Thymidine kinase not required for antiviral activity of acyclovir against mouse cytomegalovirus.

@article{Burns1981ThymidineKN,
  title={Thymidine kinase not required for antiviral activity of acyclovir against mouse cytomegalovirus.},
  author={William H. Burns and John R Wingard and W J Bender and Rein Saral},
  journal={Journal of virology},
  year={1981},
  volume={39 3},
  pages={889-93}
}
Previous studies of herpesvirus infections have indicated that a virus-specified thymidine kinase is required for the initial phosphorylation of acyclovir [acycloguanosine or 9-(2-hydroxyethoxymethyl)guanine] in the formation of acycloguanosine triphosphate. The latter compound accumulates in infected cells and competitively inhibits the viral DNA polymerase. We found that mouse cytomegalovirus, which does not express a thymidine kinase, was sensitive to the antiviral effects of acyclovir at a… CONTINUE READING
7 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-7 of 7 extracted citations

Similar Papers

Loading similar papers…