Thymidine kinase in malignant melanoma

@article{Borovansk1994ThymidineKI,
  title={Thymidine kinase in malignant melanoma},
  author={Jan Borovansk{\'y} and Jana Stribrna and Milan Elleder and I Neti´kov{\'a}},
  journal={Melanoma Research},
  year={1994},
  volume={4},
  pages={275-279}
}
Thymidine kinase (EC 2.7.1.21) Is an enzyme supporting DNA synthesis under conditions of increased cell proliferation. Although it has proved to be a useful marker for various malignant diseases, it has not been tested in malignant melanoma. Thymidine kinase activity was measured by means of a radioenzymic assay in two classical animal models of melanoma disease — B16 and Cloudman S91 melanoma-bearing mice. Tumour cell proliferation was assessed histochemically by measuring the expression of… 

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