Thymidine kinase as a predictor of response to chemotherapy in advanced breast cancer

  title={Thymidine kinase as a predictor of response to chemotherapy in advanced breast cancer},
  author={Hui-Jian Zhang and Brian J. Kennedy and David T. Kiang},
  journal={Breast Cancer Research and Treatment},
SummaryCytosols from breast cancers were measured for estrogen receptor (ER) and thymidine kinase (TK) activity. There was no correlation between ER and TK in 137 primary breast cancers studied. The results of TK from 57 metastatic breast cancers were correlated with the response or failure to subsequent hormonal therapy or chemotherapy. TK did not predict the responses to hormonal therapy in 12 patients. Of the 45 patients treated with chemotherapies, 13 of 15 tumors with TK over 80 pmol/mg… 

Predicting chemosensitivity of tumors

Testing of the sensitivity of human tumors to anticancer drugs received a fresh impetus from the introduction of clonogenic assays by Salmon and Hamburger (1) and renewed the interest of clinical

Methylsulfonylmethane Suppresses Breast Cancer Growth by Down-Regulating STAT3 and STAT5b Pathways

In this study, it is demonstrated that MSM substantially decreased the viability of human breast cancer cells in a dose-dependent manner and confirmed that MSM can effectively regulate multiple targets including STAT3/VEGF and STAT5b/IGF-1R.

Neuron specific enolase (NSE) and thymidine kinase (TK) as markers in biological fluids of brain tumor patients

Serum TK seems to be a useful marker for following up cerebral tumors after surgery, but NSE is less useful for this purpose, and most of the TK activity above the cut-off value was found in the tumor group.

Increases in estrogen receptor‐α concentration in breast cancer cells promote serine 118/104/106‐independent AF‐1 transactivation and growth in the absence of estrogen

The results suggest that elevated levels of ERα in breast cancer cells can result in activation of receptor transcriptional function in a manner distinct from classical mechanisms that involve ligand binding or growth factor‐induced phosphorylation, and describe a potential mechanism whereby increases in ERα concentration may provide a proliferative advantage by augmenting ERα function regardless of ligand status.



Estrogen receptors and responses to chemotherapy and hormonal therapy in advanced breast cancer.

Analysis of clinical data of patients with advanced breast cancer suggests that separate factors associated with the response to chemotherapy may coexist with estrogen receptors in breast cancer.

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It is concluded that estrogen-receptor values are an important predictor of response to cytotoxic chemotherapy in metastatic breast cancer.

Evaluation of estrogen receptor assays in human breast cancer tissue.

It is concluded that, in spite of the lack of specificity controls inherent in the sophisticated standard assays, the simplified DCC assay might be useful if the biopsy specimen is too small to provide the number of aliquots for a standard D CC assay or sufficient protein for a sucrose gradient analysis.

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A consensus-development meeting on "Steroid Receptors in Breast Cancer" was held at the National Institutes of Health on June 27–29 and concluded with a round-table discussion on the impact of receptor assays on the management of the patient with breast cancer.

Purification and properties of estrogen-responsive cytoplasmic thymidine kinase from human breast cancer.

The effect of 17 beta-estradiol on cytoplasmic thymidine kinase activity was studied in MCF-7, a human breast cancer cell line in culture which responds to estrogens with an increase in the rate of

Send This Patient's Tumor for Culture and Sensitivity

The human tumor stem-cell assay, a new in vitro test for determining the sensitivity or resistance of an individual patient's tumor to an anticancer drug, is reported.

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    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer
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A system is proposed by the UICC for assessing response to treatment of advanced breast cancers and its application in clinical practice is proposed.