Thymidine kinase and thymidylate synthase in advanced breast cancer: response to tamoxifen and chemotherapy.


Thymidylate synthase (TS) is a crucial target for 5-fluorouracil (5-FU) in the de novo pathway of pyrimidine synthesis, which is necessary for DNA synthesis. Thymidine kinase (TK) plays a key role in the complementary or alternative salvage pathway of pyrimidine synthesis in acute or pathological tissue stress. In the present study, the activity levels of… (More)


2 Figures and Tables

Slides referencing similar topics