Thymidine-induced mutations in mammalian cells: sequence specificity and implications for mutagenesis in vivo.

Abstract

Imbalances in the intracellular nucleotide precursor pools in mammalian cells can result in the induction of mutations during the DNA replication process. By using a shuttle vector system developed in our laboratory, we have analyzed the sequence specificity of mutations induced in mouse A9 cells by exposure of the cells to a high concentration of thymidine… (More)

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@article{Kresnak1992ThymidineinducedMI, title={Thymidine-induced mutations in mammalian cells: sequence specificity and implications for mutagenesis in vivo.}, author={M T Kresnak and R. L. Davidson}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1992}, volume={89 7}, pages={2829-33} }