Thymidine glycol: the effect on DNA molecular structure and enzymatic processing.

@article{Dolinnaya2013ThymidineGT,
  title={Thymidine glycol: the effect on DNA molecular structure and enzymatic processing.},
  author={Nina G. Dolinnaya and Elena Kubareva and Elena A. Romanova and Roman M. Trikin and Tatiana Semenovna Oretskaya},
  journal={Biochimie},
  year={2013},
  volume={95 2},
  pages={134-47}
}
Thymine glycol (Tg) in DNA is a biologically active oxidative damage caused by ionizing radiation or oxidative stress. Due to chirality of C5 and C6 atoms, Tg exists as a mixture of two pairs of cis and trans diastereomers: 5R cis-trans pair (5R,6S; 5R,6R) and 5S cis-trans pair (5S,6R; 5S,6S). Of all the modified pyrimidine lesions that have been studied to date, only thymine glycol represents a strong block to high-fidelity DNA polymerases in vitro and is lethal in vivo. Here we describe the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 153 references

Similar Papers

Loading similar papers…