Thymic stromal lymphopoietin promotes the proliferation of human trophoblasts via phosphorylated STAT3-mediated c-Myc upregulation.

@article{Pu2012ThymicSL,
  title={Thymic stromal lymphopoietin promotes the proliferation of human trophoblasts via phosphorylated STAT3-mediated c-Myc upregulation.},
  author={Huay-min H. Pu and Jie Duan and Yufang Wang and D X Fan and Da Jin Li and Li Ping Jin},
  journal={Placenta},
  year={2012},
  volume={33 5},
  pages={387-91}
}
Our previous study has demonstrated that thymic stromal lymphopoietin (TSLP) stimulates trophoblast proliferation and invasion, suggesting TSLP plays an important role in the placentation in early human pregnancy, but the intracellular molecular mechanism is currently unknown. The present study is undertaken to investigate whether the STAT3-c-Myc signaling pathway is involved in TSLP-mediated trophoblast proliferation. Primary human first-trimester trophoblasts were treated with TSLP only, or… CONTINUE READING