Thymic stromal lymphopoietin links keratinocytes and dendritic cell-derived IL-23 in patients with psoriasis.

@article{Volpe2014ThymicSL,
  title={Thymic stromal lymphopoietin links keratinocytes and dendritic cell-derived IL-23 in patients with psoriasis.},
  author={Elisabetta Volpe and Lucia Pattarini and Carolina Mart{\'i}nez-Cingolani and Stephan Meller and Marie-H{\'e}l{\`e}ne Donnadieu and Sofia I. Bogiatzi and Mar{\'i}a Isabel Fern{\'a}ndez and Maxime Touzot and Jean-Christophe Bichet and Fabien Reyal and Maria Paola Paronetto and Andrea Chiricozzi and Sergio Chimenti and Francesca Nasorri and Andrea Cavani and Andreas Kislat and Bernhard Homey and Vassili Soumelis},
  journal={The Journal of allergy and clinical immunology},
  year={2014},
  volume={134 2},
  pages={373-81}
}
BACKGROUND Thymic stromal lymphopoietin (TSLP) is a major proallergic cytokine that promotes TH2 responses through dendritic cell (DC) activation. Whether it also plays a role in human autoimmune inflammation and associated pathways is not known. OBJECTIVE In this study we investigated the potential role of several epithelium-derived factors, including TSLP, in inducing IL-23 production by human DCs. We further dissected the role of TSLP in patients with psoriasis, an IL-23-associated skin… CONTINUE READING
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