Thymic stromal lymphopoietin deficiency attenuates experimental autoimmune encephalomyelitis.

@article{Eckhardt2015ThymicSL,
  title={Thymic stromal lymphopoietin deficiency attenuates experimental autoimmune encephalomyelitis.},
  author={Jenny Eckhardt and Marina Doebbeler and Christina Koenig and Katarzyna Kuczera and Christine Kuhnt and Christian Ostalecki and Elisabeth Zinser and Tak W Mak and Alexander Steinkasserer and Matthias Lechmann},
  journal={Clinical and experimental immunology},
  year={2015},
  volume={181 1},
  pages={51-64}
}
In the present study we examined the role of thymic stromal lymphopoietin (TSLP) in experimental autoimmune encephalomyelitis (EAE). Here, we report that TSLP knock-out (KO) mice display a delayed onset of disease and an attenuated form of EAE. This delayed onset was accompanied by a reduced number of encephalitogenic T helper type 1 (Th1) cells in the central nervous system (CNS) of TSLP KO mice. In addition, CD4(+) and CD8(+) T cells from CNS of TSLP KO mice show a reduced activation status… CONTINUE READING
1 Citations
65 References
Similar Papers

Citations

Publications citing this paper.

References

Publications referenced by this paper.
Showing 1-10 of 65 references

Th1 versus Th17

  • AE Lovett-Racke, Y Yang, MK. Racke
  • NOL
  • 2012

CC chemokine recep

  • C Trebst, SM Staugaitis, P Kivisakk
  • 2011

Similar Papers

Loading similar papers…