Thymic stromal lymphopoietin-activated invariant natural killer T cells trigger an innate allergic immune response in atopic dermatitis.

@article{Wu2010ThymicSL,
  title={Thymic stromal lymphopoietin-activated invariant natural killer T cells trigger an innate allergic immune response in atopic dermatitis.},
  author={Wen Hao Wu and Chang Ook Park and Sang Ho Oh and Hee Jung Kim and Yeon Sook Kwon and Byung Gi Bae and Ji Yeon Noh and Kwang Hoon Lee},
  journal={The Journal of allergy and clinical immunology},
  year={2010},
  volume={126 2},
  pages={290-9, 299.e1-4}
}
BACKGROUND Although invariant natural killer T (iNKT) cells have been shown to play a critical role in the pathogenesis of asthma, the role of iNKT cells in atopic dermatitis (AD) has not been well evaluated. OBJECTIVE We investigated whether iNKT cells in patients with AD increased and whether iNKT cells were activated by thymic stromal lymphopoietin (TSLP), which is highly expressed in keratinocytes of AD. METHODS We assessed the population of iNKT cells in PBMCs of patients with AD and… CONTINUE READING
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