Thymic selection by a single MHC/peptide ligand produces a semidiverse repertoire of CD4+ T cells.

@article{Surh1997ThymicSB,
  title={Thymic selection by a single MHC/peptide ligand produces a semidiverse repertoire of CD4+ T cells.},
  author={Charles D. Surh and D S Lee and Wai-Ping Fung-Leung and L. K. J. Karlsson and Jonathan Sprent},
  journal={Immunity},
  year={1997},
  volume={7 2},
  pages={209-19}
}
The influence of individual peptides in thymic selection was examined in H2-M- mice, in which positive selection is directed to a single peptide, class II-associated invariant chain peptide (CLIP) bound to H2-A(b). Two sensitive in vivo approaches showed that 70%-80% of CD4+ T cells undergoing positive selection to CLIP+H2-A(b) have self-reactivity to the various peptides expressed on wild-type H2-M+ antigen-presenting cells. When these self-reactive T cells were depleted, the residual CD4… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 62 extracted citations

Similar Papers

Loading similar papers…