Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

@article{Teh1988ThymicMH,
  title={Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells},
  author={Hung Sia Teh and Pawel Kisielow and Bernadette Scott and Hiroyuki Kishi and Yasushi Uematsu and Horst Bluethmann and Harald von Boehmer},
  journal={Nature},
  year={1988},
  volume={335},
  pages={229-233}
}
T-cell receptors and T-cell subsets were analysed in T-cell receptor transgenic mice expressing α and β T-cell receptor genes isolated from a male-specific, H–2Db-restricted CD4–8+ T-cell clone. The results indicate that the specific interaction of the T-cell receptor on immature thymocytes with thymic major histocompatibility complex antigens determines the differentiation of CD4+8+ thymocytes into either CD4+8– or CD4–8+ mature T cells. 

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