Thymic-independent T cell regeneration occurs via antigen-driven expansion of peripheral T cells resulting in a repertoire that is limited in diversity and prone to skewing.

@article{Mackall1996ThymicindependentTC,
  title={Thymic-independent T cell regeneration occurs via antigen-driven expansion of peripheral T cells resulting in a repertoire that is limited in diversity and prone to skewing.},
  author={Crystal L Mackall and Catherine V. Bare and Larry Granger and Susan O. Sharrow and Julie A. Titus and Ronald E Gress},
  journal={Journal of immunology},
  year={1996},
  volume={156 12},
  pages={4609-16}
}
Thymic regenerative capacity in humans decreases with age, suggesting that thymic-independent pathways of T cell regeneration may predominate during adulthood. Using a murine bone marrow transplantation model, we present evidence that thymic-independent T cell regeneration occurs primarily via expansion of peripheral T cells and is Ag driven since significant expansion of CD4+ or CD8+ transgenic (Tg+)/TCR-bearing cells occurs only in the presence of Ag specific for the TCR. Such expansion… CONTINUE READING