Thymic emigration revisited

  title={Thymic emigration revisited},
  author={Tom M. McCaughtry and Matthew S. Wilken and Kristin A Hogquist},
  journal={The Journal of Experimental Medicine},
  pages={2513 - 2520}
Conventional alphabeta T cell precursors undergo positive selection in the thymic cortex. When this is successful, they migrate to the medulla and are exposed to tissue-specific antigens (TSA) for purposes of central tolerance, and they undergo maturation to become functionally responsive T cells. It is commonly understood that thymocytes spend up to 2 wk in the medulla undergoing these final maturation steps before emigrating to peripheral lymphoid tissues. In addition, emigration is thought… CONTINUE READING
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Thymic microvascular system

  • T. Ushiki
  • Microsc . Res . Tech .
  • 1997

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