Thymic atrophy in murine acute graft-versus-host disease is effected by impaired cell cycle progression of host pro-T and pre-T cells.

@article{Krenger2000ThymicAI,
  title={Thymic atrophy in murine acute graft-versus-host disease is effected by impaired cell cycle progression of host pro-T and pre-T cells.},
  author={Werner Krenger and Simona Rossi and Luca Piali and Georg A. Hollaender},
  journal={Blood},
  year={2000},
  volume={96 1},
  pages={347-54}
}
Reconstitution of the peripheral T-cell compartment is a critical aspect for the success of bone marrow transplantation and is also dependent on the reestablishment of normal thymic structure and function. Graft-versus-host disease (GVHD), however, exacerbates posttransplant immunodeficiency through a deleterious effect on thymic function. To investigate the mechanisms of GVHD-mediated thymic disease, 2 murine parent-->F(1 )transplantation models of acute and chronic GVHD, respectively, were… CONTINUE READING
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mic microenvironments , 3 - D versus 2 - D ?

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