Thymic Versus Induced Regulatory T Cells – Who Regulates the Regulators?

  title={Thymic Versus Induced Regulatory T Cells – Who Regulates the Regulators?},
  author={Giovanni Antonio Maria Povoleri and Cristiano Scott{\'a} and Estefania Andrea Nova-Lamperti and Susan D. John and Giovanna Lombardi and Behdad Afzali},
  booktitle={Front. Immunol.},
Physiological health must balance immunological responsiveness against foreign pathogens with tolerance toward self-components and commensals. Disruption of this balance causes autoimmune diseases/chronic inflammation, in case of excessive immune responses, and persistent infection/immunodeficiency if regulatory components are overactive. This homeostasis occurs at two different levels: at a resting state to prevent autoimmune disease, as autoreactive effector T-cells (Teffs) are only partially… CONTINUE READING
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