Thymic T cells are driven to expand upon interaction with self-class II major histocompatibility complex gene products on accessory cells.

@article{Rock1984ThymicTC,
  title={Thymic T cells are driven to expand upon interaction with self-class II major histocompatibility complex gene products on accessory cells.},
  author={Kenneth L. Rock and Baruj Benacerraf},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1984},
  volume={81 4},
  pages={1221-4}
}
Murine thymocytes induce the monokine interleukin 1 upon in vitro coculture with a radioresistant Ia-bearing accessory cell [murine Ia molecule is a class II major histocompatibility complex (MHC) antigen]. The generation of interleukin 1 is critically dependent on the function of I-region gene products on accessory cells. The induced interleukin 1 appears to allow the activation and proliferation of self-MHC-specific thymocytes. Thus, in the absence of added exogenous factors, there is an Ia… CONTINUE READING