Thymic DCs derived IL-27 regulates the final maturation of CD4+ SP thymocytes

@inproceedings{Tang2016ThymicDD,
  title={Thymic DCs derived IL-27 regulates the final maturation of CD4+ SP thymocytes},
  author={Hui Tang and Jie Zhang and Xiuyuan Sun and Xiaoping Qian and Yu Zhang and Rong De Jin},
  booktitle={Scientific reports},
  year={2016}
}
IL-27, as a pleiotropic cytokine, promotes the differentiation of naïve T cells to Th1, while suppressing Th2 and Th17 differentiation in the periphery. However, the role of IL-27 in the thymocyte development remains unknown. Here we showed that IL-27 was highly expressed in thymic plasmacytoid dendritic cells (pDCs) while its receptor expression was mainly… CONTINUE READING