Thymic CD8+ T cell production strongly influences tumor antigen recognition and age-dependent glioma mortality.

Abstract

For unknown reasons, advanced age remains a dominant predictor of poor clinical outcome for nearly all cancers. A decrease in the production of T cells by the thymus accompanies normal aging and parallels the age-dependent increase in cancer progression, but the specific impact of immunity on tumor progression in general is unknown. Glioblastoma multiforme… (More)

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