Thy-1 promoter hypermethylation: a novel epigenetic pathogenic mechanism in pulmonary fibrosis.

  title={Thy-1 promoter hypermethylation: a novel epigenetic pathogenic mechanism in pulmonary fibrosis.},
  author={Yan Y Sanders and Annie Pardo and Mois{\'e}s Selman and Gerard J Nuovo and Trygve O. Tollefsbol and Gene P. Siegal and James S. Hagood},
  journal={American journal of respiratory cell and molecular biology},
  volume={39 5},
Mechanisms regulating myofibroblastic differentiation of fibroblasts within fibroblastic foci in idiopathic pulmonary fibrosis (IPF) remain unclear. Epigenetic processes, including DNA methylation, produce heritable but potentially reversible changes in DNA or its associated proteins and are prominent in development and oncogenesis. We have shown that Thy-1 suppresses myofibroblastic differentiation of lung fibroblasts and that fibroblasts in fibroblastic foci are Thy-1(-). Epigenetic down… CONTINUE READING


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