Thy-1, a novel marker for angiogenesis upregulated by inflammatory cytokines.

@article{Lee1998Thy1AN,
  title={Thy-1, a novel marker for angiogenesis upregulated by inflammatory cytokines.},
  author={Woo Song Lee and Mukesh K Jain and Burak M. Arkonac and Dongming Zhang and Stanley Y. Shaw and Shinji Kashiki and Koji Maemura and Stephanie L. Lee and Norman Kenneth Hollenberg and Margaret Ellen Lee and Edgar Haber},
  journal={Circulation research},
  year={1998},
  volume={82 8},
  pages={
          845-51
        }
}
We identified the cell surface glycoprotein Thy-1 on the endothelium of newly formed blood vessels in four models of angiogenesis in adult rats. Anti-Thy-1 staining showed that Thy-1 was upregulated in adventitial blood vessels after balloon injury to the carotid artery. Preabsorption with a rat Thy-1-Ig fusion construct eliminated all immunoreactivity and thus confirmed the specificity of the Thy-1 staining. Thy-1 was also expressed in the endothelium of small blood vessels formed after tumor… CONTINUE READING

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