Thunderstorm Asthma Due to Grass Pollen

@article{Suphioglu1998ThunderstormAD,
  title={Thunderstorm Asthma Due to Grass Pollen},
  author={Cenk Suphioglu},
  journal={International Archives of Allergy and Immunology},
  year={1998},
  volume={116},
  pages={253 - 260}
}
  • C. Suphioglu
  • Published 1 August 1998
  • Environmental Science
  • International Archives of Allergy and Immunology
It is widely known and accepted that grass pollen is a major outdoor cause of hay fever. Moreover, grass pollen is also responsible for triggering allergic asthma, gaining impetus as a result of the 1987/1989 Melbourne and 1994 London thunderstorm–associated asthma epidemics. However, grass pollen is too large to gain access into the lower airways to trigger the asthmatic response and micronic particles <5 μm are required to trigger the response. We have successfully shown that ryegrass pollen… 

Figures from this paper

Ability of Pollen Cytoplasmic Granules to Induce Biased Allergic Responses in a Rat Model
TLDR
PCGs, able to deeply penetrate in the respiratory tract, induced local and strong allergic and inflammatory responses more linked with asthma- than rhinitis-related allergic symptoms.
A trans-disciplinary overview of case reports of thunderstorm-related asthma outbreaks and relapse
TLDR
The purpose of this article is to gather existing trans-disciplinary data on thunderstorm-related asthma attacks and potential relapse in the same patient and to know the mechanisms involved in the release of allergens from airborne pollen grains during thunderstorms and the associated risk in view of prevention.
Importance of allergen–environment interactions in epidemic thunderstorm asthma
Australia is home to one of the highest rates of allergic rhinitis worldwide. Commonly known as ‘hay fever’, this chronic condition affects up to 30% of the population and is characterised by
Thunderstorm‐related asthma: what happens and why
TLDR
All subjects affected by pollen allergy should be alerted to the danger of being outdoors during a thunderstorm in the pollen season, as such events may be an important cause of severe exacerbations and thus minimize thunderstorm‐related events.
Immunological Interactive Effects between Pollen Grains and Their Cytoplasmic Granules on Brown Norway Rats
TLDR
For humoral and cellular allergic responses, interactive effects between the 2 aeroallergenic sources used in this study seem to be influenced mainly by PCGs.
Allergens and thunderstorm asthma
TLDR
This review focuses on important advances in the understanding of the mechanism of the role of allergens, in particular fungal spores such as Alternaria, in asthma epidemics associated with thunderstorms.
Concentrations of major grass group 5 allergens in pollen grains and atmospheric particles: implications for hay fever and allergic asthma sufferers sensitized to grass pollen allergens
  • Schäppi, Taylor, Suphioglu
  • Environmental Science
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 1999
TLDR
Pollen counts provide a guide to hay fever sufferers because grass pollen, because of its size, has a low probability of entering the lower airways to trigger asthma.
Impact of pollen.
TLDR
There is a need for a definition of threshold pollen levels within the public, the policymakers and the pharmaceutical industry and a first approach could be to define preliminary threshold values for different regions, followed by a validation of these preliminary threshold levels with patient symptom scores that can be collected by using new information and communication technology (ICT).
A systematic review of the role of grass pollen and fungi in thunderstorm asthma.
...
...

References

SHOWING 1-10 OF 47 REFERENCES
Mechanism of grass-pollen-induced asthma
Where is the allergic reaction in ragweed asthma?
Major grass pollen allergen Lol p 1 binds to diesel exhaust particles: implications for asthma and air pollution
  • R. Knox, C. Suphioglu, L. Bursill
  • Environmental Science
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 1997
TLDR
This data indicates that the presence of grass pollen allergens in the atmosphere is associated with epidemics of thunderstorm asthma during the grass pollen season and the question arises whether these particles can interact with other sources of fine particles, particularly those present during episodes of air pollution.
Source of Bet v 1 loaded inhalable particles from birch revealed
TLDR
The hypothesis that airborne birch pollen grains settle on nearby leaf surfaces; (2) then, following light rainfall, the grains germinate and, (3) later, pollen tubes burst, releasing inhalable particles carrying Bet v 1 into the atmospheric aerosol is proposed.
Evidence of grass‐pollen allergenic activity in the smaller micronic atmospheric aerosol fraction
  • F. Spieksma, J. Kramps, J. Dijkman
  • Environmental Science
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 1990
TLDR
Sampling observations during a period with relatively high airborne grass‐ pollen concentrations showed reliably detectable amounts of grass‐pollen allergen, not only in the first impaction stage where intact pollen were collected, but also in the lower stages collecting the smaller, paucimicronic and submicron atmospheric aerosol fraction.
Deposition of inhaled pollen and pollen extract in human airways.
IT is generally assumed that airborne grass-pollen grains are directly inhaled into the lungs and thereby lead to the development of the signs and symptoms of asthma in susceptible persons. This
The role of ragweed pollen in autumnal asthma.
CHILDHOOD ASTHMA AND GRASS POLLEN AEROBIOLOGY IN MELBOURNE
Children from the Melbourne metropolitan area with laboratory proven bronchial sensitivity to ryegrass pollen were selected for a clinical trial which was run concurrently with an aerobiological
...
...