Thunderous nuclear reactions

  title={Thunderous nuclear reactions},
  author={Leonid Babich},
that anchor the peptide’s carboxy terminus in a pocket of the MHC class I molecule’s peptidebinding groove. The structure of MHC class I molecules in complex with TAPBPR shows that the latter molecule does not detectably interact with ERp57, and that its binding site on the MHC class I molecule overlaps with the tapasin binding site. A structural feature of TAPBPR dubbed the scoop loop helps to displace peptides that have modest affinity for the MHC molecule by competing for interaction with… CONTINUE READING