Thujone Exhibits Low Affinity for Cannabinoid Receptors But Fails to Evoke Cannabimimetic Responses

@article{Meschler1999ThujoneEL,
  title={Thujone Exhibits Low Affinity for Cannabinoid Receptors But Fails to Evoke Cannabimimetic Responses},
  author={J. P. Meschler and A. Howlett},
  journal={Pharmacology Biochemistry and Behavior},
  year={1999},
  volume={62},
  pages={473-480}
}
  • J. P. Meschler, A. Howlett
  • Published 1999
  • Chemistry, Medicine
  • Pharmacology Biochemistry and Behavior
    • Absinthe, an abused drug in the early 1900s, has been speculated to activate the receptors responsible for marijuana intoxication (the CB1 cannabinoid receptor) (Nature 253:365-356; 1975). To test this hypothesis, we investigated oil of wormwood (Artemisia absinthium) the active plant product found in absinthe, and thujone, the active compound found in oil of wormwood. Radioligand receptor binding assays employing membrane preparations from rat brains containing CB1 cannabinoid receptors, and… CONTINUE READING
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    References

    SHOWING 1-10 OF 27 REFERENCES
    Nonclassical cannabinoid analgetics inhibit adenylate cyclase: development of a cannabinoid receptor model.
    • 238
    Cannabinoid receptor agonists and antagonists
    • 56
    In vivo characterization of a specific cannabinoid receptor antagonist (SR141716A): inhibition of delta 9-tetrahydrocannabinol-induced responses and apparent agonist activity.
    • 368
    Determination and characterization of a cannabinoid receptor in rat brain.
    • 2,088
    • PDF
    Differential receptor-G-protein coupling evoked by dissimilar cannabinoid receptor agonists.
    • 61
    Cannabinoid receptor stimulation of guanosine-5'-O-(3-[35S]thio)triphosphate binding in rat brain membranes.
    • 105
    Cannabinoid inhibition of adenylate cyclase. Biochemistry of the response in neuroblastoma cell membranes.
    • A. Howlett
    • Chemistry, Medicine
    • Molecular pharmacology
    • 1985
    • 251
    SR141716A, a potent and selective antagonist of the brain cannabinoid receptor
    • 1,697
    Pharmacology of cannabinoid receptors.
    • A. Howlett
    • Biology, Medicine
    • Annual review of pharmacology and toxicology
    • 1995
    • 467
    Porphyrogenic properties of the terpenes camphor, pinene, and thujone (with a note on historic implications for absinthe and the illness of Vincent van Gogh).
    • 71