Thujone Exhibits Low Affinity for Cannabinoid Receptors But Fails to Evoke Cannabimimetic Responses

  title={Thujone Exhibits Low Affinity for Cannabinoid Receptors But Fails to Evoke Cannabimimetic Responses},
  author={J. P. Meschler and A. Howlett},
  journal={Pharmacology Biochemistry and Behavior},
  • J. P. Meschler, A. Howlett
  • Published 1999
  • Chemistry, Medicine
  • Pharmacology Biochemistry and Behavior
  • Absinthe, an abused drug in the early 1900s, has been speculated to activate the receptors responsible for marijuana intoxication (the CB1 cannabinoid receptor) (Nature 253:365-356; 1975). To test this hypothesis, we investigated oil of wormwood (Artemisia absinthium) the active plant product found in absinthe, and thujone, the active compound found in oil of wormwood. Radioligand receptor binding assays employing membrane preparations from rat brains containing CB1 cannabinoid receptors, and… CONTINUE READING
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