Thujone Exhibits Low Affinity for Cannabinoid Receptors But Fails to Evoke Cannabimimetic Responses

@article{Meschler1999ThujoneEL,
  title={Thujone Exhibits Low Affinity for Cannabinoid Receptors But Fails to Evoke Cannabimimetic Responses},
  author={Justin P Meschler and Allyn C. Howlett},
  journal={Pharmacology Biochemistry and Behavior},
  year={1999},
  volume={62},
  pages={473-480}
}
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100 Citations
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100 Citations

α-Thujone reduces 5-HT3 receptor activity by an effect on the agonist-induced desensitization

The Effects of Thujone on the Function of Nicotinic Acetylcholine Receptors

Thujone inhibits human nAChRs with different potencies using the two electrode voltage clamp method and was found to be independent of membrane potential and did not compete with ACh.

Monoterpene α-thujone exerts a differential inhibitory action on GABA(A) receptors implicated in phasic and tonic GABAergic inhibition.

Modulation of GABAergic synaptic currents and current responses by α-thujone and dihydroumbellulone.

Analysis of current responses to exogenous GABA revealed that 1a reduced their amplitude, affecting their onset, desensitization, and deactivation, suggesting an effect on receptor gating, supporting the effects of 1a on GABAergic inhibition as being due to specific interactions with GABA(A)Rs.

Alpha-thujone (the active component of absinthe): gamma-aminobutyric acid type A receptor modulation and metabolic detoxification.

Alpha-thujone in absinthe and herbal medicines is a rapid-acting and readily detoxified modulator of the GABA-gated chloride channel.

Small Molecules from Nature Targeting G-Protein Coupled Cannabinoid Receptors: Potential Leads for Drug Discovery and Development

An overview of therapeutic potential of ligands and plants modulating cannabinoid receptors that may be of interest to pharmaceutical industry in search of new and safer drug discovery and development for future therapeutics is provided.

Thujone and thujone-containing herbal medicinal and botanical products: toxicological assessment.

Absinthe and gamma-aminobutyric acid receptors.

  • R. Olsen
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2000
Evidence that thujone acts as a γ-aminobutyric acid type A (GABAA) receptor chloride channel blocker, much like the plant convulsant picrotoxin, and related synthetic analogs is provided.

Thujone, a widely debated volatile compound: What do we know about it?

Experimental results show that the phenotypic manifestation and quantity of thujones in the essential oils depend on the plant organ and its developmental phase, and it would be necessary to do further systematic studies from the plant biological, toxicological and pharmaco-kinetic points of view to optimise the safe use ofThujones.

Thujone, a widely debated volatile compound: What do we know about it?

Experimental results show that the phenotypic manifestation and quantity of thujones in the essential oils depend on the plant organ and its developmental phase, as well as the weather conditions and growth habitat, which might influence the ratios and the possibly unique responses of the individual species.
...

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