Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins

@article{Mills2010ThrowingTC,
  title={Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins},
  author={Alea A. Mills},
  journal={Nature Reviews Cancer},
  year={2010},
  volume={10},
  pages={669-682}
}
The discovery that cancer can be governed above and beyond the level of our DNA presents a new era for designing therapies that reverse the epigenetic state of a tumour cell. Understanding how altered chromatin dynamics leads to malignancy is essential for controlling tumour cells while sparing normal cells. Polycomb and trithorax group proteins are evolutionarily conserved and maintain chromatin in the 'off' or 'on' states, thereby preventing or promoting gene expression, respectively. Recent… CONTINUE READING