Through thick and thin: the conundrum of chromatin fibre folding in vivo.

Abstract

DNA in a human cell is approximately 2 m long but is compacted into micrometre-sized eukaryotic nuclei. To achieve this level of compaction, DNA is first wrapped up into nucleosomes, which are then thought to fold into fibres and loops. The basal unit of such folding is the 10 nm ‘beads on a string’ structure observed in all eukaryotic cells (Fig 1A… (More)
DOI: 10.1038/embor.2012.143

Topics

1 Figure or Table

Cite this paper

@article{Qunet2012ThroughTA, title={Through thick and thin: the conundrum of chromatin fibre folding in vivo.}, author={Delphine Qu{\'e}net and James G. McNally and Yamini Dalal}, journal={EMBO reports}, year={2012}, volume={13 11}, pages={943-4} }