Thromboxane stimulates synthesis of extracellular matrix proteins in vitro.

  title={Thromboxane stimulates synthesis of extracellular matrix proteins in vitro.},
  author={Leslie A. Bruggeman and Elizabeth A. Horigan and Satoshi Horikoshi and Patricio E. Ray and Paul E. Klotman},
  journal={The American journal of physiology},
  volume={261 3 Pt 2},
The vasoconstrictor eicosanoid thromboxane plays an important role in the pathogenesis of several renal diseases. As an autacoid, its local release alters blood flow and induces platelet aggregation. We report a direct stimulatory effect of thromboxane on extracellular matrix protein production and gene expression in vitro. Treatment of two cell types, differentiated mouse teratocarcinoma cells (F9+) and human glomerular mesangial cells, with two different thromboxane analogues resulted in… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 16 extracted citations

Similar Papers

Loading similar papers…