Thromboxane stimulates synthesis of extracellular matrix proteins in vitro.

@article{Bruggeman1991ThromboxaneSS,
  title={Thromboxane stimulates synthesis of extracellular matrix proteins in vitro.},
  author={Leslie A. Bruggeman and Elizabeth A. Horigan and Satoshi Horikoshi and Patricio E. Ray and Paul E. Klotman},
  journal={The American journal of physiology},
  year={1991},
  volume={261 3 Pt 2},
  pages={F488-94}
}
The vasoconstrictor eicosanoid thromboxane plays an important role in the pathogenesis of several renal diseases. As an autacoid, its local release alters blood flow and induces platelet aggregation. We report a direct stimulatory effect of thromboxane on extracellular matrix protein production and gene expression in vitro. Treatment of two cell types, differentiated mouse teratocarcinoma cells (F9+) and human glomerular mesangial cells, with two different thromboxane analogues resulted in… CONTINUE READING

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