Thromboxane-prostanoid receptor expression and antagonism in dextran-sodium sulfate-induced colitis

  title={Thromboxane-prostanoid receptor expression and antagonism in dextran-sodium sulfate-induced colitis},
  author={Patsy R. Carter and Robert M. McElhatten and Songlin Zhang and William S. Wright and Norman R. Harris},
  journal={Inflammation Research},
In the current study of murine colitis, the potential roles of thromboxane and the thromboxane-prostanoid (TP) receptor were investigated, in as much as thromboxane signaling has been implicated in human inflammatory bowel disease. Colitis was induced in C57BL/6 mice via ingestion of dextran sodium sulfate (DSS), with or without co-administration of the thromboxane synthase inhibitor ozagrel (25 mg/kg/day) or the TP receptor antagonist vapiprost (2.5 mg/kg/day). Immunohistochemistry of colonic… CONTINUE READING


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