Thromboxane-induced actin polymerization in hypoxic pulmonary artery is independent of Rho.


Actin polymerization (APM), regulated by Rho GTPases, promotes myocyte force generation. Hypoxia is known to impede postnatal disassembly of the actin cytoskeleton in pulmonary arterial (PA) myocytes. We compared basal and agonist-induced APM in myocytes from PA and descending aorta (Ao), under hypoxic and normoxic conditions. We also examined effects of… (More)
DOI: 10.1152/ajplung.00016.2011


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