Thromboxane A2 and related prostaglandins in airways

@article{Devillier1997ThromboxaneAA,
  title={Thromboxane A2 and related prostaglandins in airways},
  author={P. Devillier and G. Bessard},
  journal={Fundamental & Clinical Pharmacology},
  year={1997},
  volume={11}
}
  • P. Devillier, G. Bessard
  • Published 1997
  • Medicine
  • Fundamental & Clinical Pharmacology
    • Summary— Asthma is now thought to be a chronic inflammatory disease of the airways. The roles of prostanoids, thromboxane A2 (TXA2) and the prostaglandins (PGs) in the pathogenesis and pathophysiology of asthma have fostered a wealth of studies but remain controversial. TXA2 and the bronchoconstrictor PGs, PGD2 and PGF2α, are generated in greater amounts in asthmatic than in normal subjects. TXA2 is a potent constrictor of airway smooth muscle, an inducer of acetylcholine release and of airway… CONTINUE READING
    View on Wiley
    ncbi.nlm.nih.gov
    71 Citations
    Highly Influential Citations
    3
    Background Citations
    24
    Results Citations
    1
    71 Citations
    Citation Type

    Citation Type

    Thromboxane A2 Inhibition
    • 19
    Therapeutic potential of thromboxane inhibitors in asthma
    • 37
    Revisiting the usefulness of thromboxane-A2 modulation in the treatment of bronchoconstriction in asthma.
    • 3
    • Highly Influenced
    Platelet Thromboxane Receptors: Biology and Function
    • 2
    NTP42, a novel antagonist of the thromboxane receptor, attenuates experimentally induced pulmonary arterial hypertension
    • 3
    An experimental study of mediators in allergic bronchoconstriction with focus on eicosanoids
    Thromboxane Prostanoid Receptor Activation Amplifies Airway Stretch-Activated Contractions Assessed in Perfused Intact Bovine Bronchial Segments
    • 6
    • Highly Influenced
    • PDF
    Leukotriene Receptor Antagonists and Antiallergy Drugs.
    • 11
    Effects of the thromboxane receptor agonist U46619 and endothelin-1 on large and small airways.
    • 26
    Thromboxane prostanoid receptor in human airway smooth muscle cells: a relevant role in proliferation.
    • 47

    References

    SHOWING 1-10 OF 248 REFERENCES
    Prostaglandin D2-induced bronchoconstriction is mediated only in part by the thromboxane prostanoid receptor.
    • 73
    • PDF
    Effect of a thromboxane receptor antagonist on PGD2- and allergen-induced bronchoconstriction.
    • 133
    Thromboxane A2 biosynthesis in acute asthma and after antigen challenge.
    • 61
    A thromboxane mimetic, U-46619, produces plasma exudation in airways of the guinea pig.
    • 45
    Anaphylactic release of thromboxane A2, prostaglandin D2, and prostacyclin from human lung parenchyma.
    • 150
    Effects of a thromboxane-receptor antagonist, BAY u 3405, on prostaglandin D2- and exercise-induced bronchoconstriction.
    • 33
    Prostaglandin D2 potentiates airway responsiveness to histamine and methacholine.
    • 109
    U46619-induced bronchoconstriction in asthmatic subjects is mediated by acetylcholine release.
    • 28
    Pulmonary vascular effects of prostaglandin D2, but not its systemic vascular or airway effects, are mediated through thromboxane receptor activation.
    • 13
    • PDF
    Pulmonary synthesis, release, and metabolism of prostaglandins.
    • 36