Thromboxane A2 and related prostaglandins in airways

  title={Thromboxane A2 and related prostaglandins in airways},
  author={P. Devillier and G. Bessard},
  journal={Fundamental & Clinical Pharmacology},
  • P. Devillier, G. Bessard
  • Published 1997
  • Medicine
  • Fundamental & Clinical Pharmacology
  • Summary— Asthma is now thought to be a chronic inflammatory disease of the airways. The roles of prostanoids, thromboxane A2 (TXA2) and the prostaglandins (PGs) in the pathogenesis and pathophysiology of asthma have fostered a wealth of studies but remain controversial. TXA2 and the bronchoconstrictor PGs, PGD2 and PGF2α, are generated in greater amounts in asthmatic than in normal subjects. TXA2 is a potent constrictor of airway smooth muscle, an inducer of acetylcholine release and of airway… CONTINUE READING
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