Thromboxane–prostaglandin receptor antagonist, terutroban, prevents neurovascular events after subarachnoid haemorrhage: a nanoSPECT study in rats

@inproceedings{Lagier2019ThromboxaneprostaglandinRA,
  title={Thromboxane–prostaglandin receptor antagonist, terutroban, prevents neurovascular events after subarachnoid haemorrhage: a nanoSPECT study in rats},
  author={David Lagier and David Tonon and Philippe Garrigue and Benjamin Alain Guillet and Laura Giacomino and Jorgelina Mart{\'i}n and Nicolas J Bruder and Lionel J Velly},
  booktitle={Critical care},
  year={2019}
}
BACKGROUND Several lipid metabolites in cerebrospinal fluid are correlated with poor outcomes in aneurysmal subarachnoid haemorrhage. Most of these metabolites bind to ubiquitous thromboxane-prostaglandin (TP) receptors, causing vasoconstriction and inflammation. Here, we evaluated terutroban (TBN), a specific TP receptor antagonist, for the prevention of post-haemorrhage blood-brain barrier disruption, neuronal apoptosis and delayed cerebral hypoperfusion. METHODS The rat double subarachnoid… CONTINUE READING
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