Thrombotic thrombocytopenia with von Willebrand factor deficiency induced by botrocetin. An animal model.


Thrombotic thrombocytopenia with severe von Willebrand factor (vWF) depletion was induced in rats by intraperitoneal injection of botrocetin, a Bothrops factor requiring vWF for platelet aggregation. The vWF deficiency state with thrombocytopenia was produced in 12 animals by single or multiple injections of botrocetin. Single botrocetin injection (450… (More)


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