Thrombotic risk factors: Basic pathophysiology

@article{Martinelli2010ThromboticRF,
  title={Thrombotic risk factors: Basic pathophysiology},
  author={Ida Martinelli and Paolo Bucciarelli and Pier Mannuccio Mannucci},
  journal={Critical Care Medicine},
  year={2010},
  volume={38},
  pages={S3-S9}
}
Although venous thrombosis has been traditionally associated with stasis and hypercoagulability, arterial thrombosis is mainly associated with heightened platelet reactivity and damage to the vessel wall. Accordingly, classic risk factors for venous and arterial thrombosis are usually considered distinct. Those for the former include cancer, surgery, pregnancy, and estrogens use, whereas risk factors of arterial thrombosis include smoking, hypertension, diabetes, the metabolic syndrome, and… Expand
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References

SHOWING 1-10 OF 114 REFERENCES
Venous and arterial thrombosis: different sides of the same coin?
TLDR
It is concluded that arterial and venous thrombosis are mechanistically different, but that common risk factors are more relevant and frequent than previously thought. Expand
The metabolic syndrome and the risk of arterial and venous thrombosis.
TLDR
This review will summarize the current knowledge on the relationship between the metabolic syndrome and arterial and venous thrombosis from a pathogenic and clinical point of view. Expand
Aging and thrombosis.
TLDR
Advanced age is associated with elevated interleukin-6 (IL-6) and C-reactive protein levels, indicating an inflammatory state that may be an important stimulus for thrombus formation in the elderly. Expand
Hyperhomocysteinemia, atherosclerosis and thrombosis.
TLDR
Additional studies are needed to define whether hyperhomocysteinemia is a risk factor for thrombosis, especially of the venous circulation, and randomized, placebo-controlled, double-blind trials of the effects of homocysteine-lowering vitamins on the thromBotic risk are urgently needed. Expand
Hemostatic and inflammatory markers as risk factors for coronary disease in the elderly.
  • R. Tracy
  • Medicine
  • The American journal of geriatric cardiology
  • 2002
TLDR
Hemostatic markers that represent inflammatory processes or coagulation activation also predict future risk in older individuals, but there is little evidence for associations between cardiovascular disease risk and ambient levels of coagulations or fibrinolytic factors. Expand
Age-related changes in the hemostatic system
TLDR
Clinical and experimental evidence suggests that endothelium could play a central role in hemostatic alterations which determine a thrombophilic state in the elderly. Expand
Diabetes mellitus as a prothrombotic condition
  • P. Grant
  • Medicine
  • Journal of internal medicine
  • 2007
TLDR
The combination of increased circulating coagulation zymogens, inhibition of fibrinolysis, changes in fibrin structure/function and alterations in platelet reactivity creates a thrombotic risk clustering which underpins the development of cardiovascular disease. Expand
Cancer and venous thromboembolism.
TLDR
The evidence of the important two-way clinical correlation between cancer and venous thromboembolism dates back to Trousseau's time and there is growing evidence for their possible benefits in terms of cancer prognosis and patient survival. Expand
Genetic susceptibility to venous thrombosis.
TLDR
Conditions involving a genetic predisposition to venous thrombosis, one of the leading causes of mortality and morbidity, increases from 1 per 100,000 during childhood to 1 every 100 in old age, is discussed. Expand
Occlusive vascular diseases in oral contraceptive users. Epidemiology, pathology and mechanisms.
TLDR
Information from published studies of the epidemiology and pathology of the occlusive vascular diseases and their risk factors are integrated to identify likely explanations for pathogenesis in oral contraceptive users and to understand vascular occlusion in Oral contraceptive users. Expand
...
1
2
3
4
5
...