Thrombotic microangiopathy in metastatic melanoma patients treated with adoptive cell therapy and total body irradiation.

@article{Tseng2014ThromboticMI,
  title={Thrombotic microangiopathy in metastatic melanoma patients treated with adoptive cell therapy and total body irradiation.},
  author={Jennifer Tseng and Deborah Citrin and Meryl Waldman and Donald E. White and Steven A Rosenberg and James C Yang},
  journal={Cancer},
  year={2014},
  volume={120 9},
  pages={1426-32}
}
BACKGROUND Thrombotic microangiopathy (TMA) is a complication that developed in some patients receiving 12 Gy total body irradiation (TBI) in addition to lymphodepleting preparative chemotherapy prior to infusion of autologous tumor-infiltrating lymphocytes (TIL) with high-dose aldesleukin (IL-2). This article describes the incidence, presentation, and… CONTINUE READING