Thrombotic microangiopathy as a complication of long-term therapy with gemcitabine.

  title={Thrombotic microangiopathy as a complication of long-term therapy with gemcitabine.},
  author={Carlos D. Flombaum and Janet A. Mouradian and Ephraim S. Casper and Robert A. Erlandson and Flora Benedetti},
  journal={American journal of kidney diseases : the official journal of the National Kidney Foundation},
  volume={33 3},
Three patients with pancreatic carcinoma treated with gemcitabine for 1 year developed clinical and laboratory findings compatible with an indolent form of the hemolytic-uremic syndrome. Renal biopsy specimens in two of these patients showed the characteristic features of thrombotic microangiopathy, and a skin biopsy specimen from the third patient, who presented with livedo reticularis, showed intravascular fibrin deposition. Thrombotic microangiopathy may represent a toxic effect of long-term… CONTINUE READING


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