Thrombotic microangiopathy: new insights
@article{Benz2010ThromboticMN, title={Thrombotic microangiopathy: new insights}, author={Kerstin Benz and Kerstin Amann}, journal={Current Opinion in Nephrology and Hypertension}, year={2010}, volume={19}, pages={242–247} }
Purpose of reviewIn the following study new aspects and insights into the epidemiology, pathogenesis and typical morphology of kidney involvement in thrombotic microangiopathy (TMA) are discussed. TMA comprises a spectrum of microvascular thrombosis syndromes associated with multiple pathogenetic factors, that is, typical and atypical haemolytic uraemic syndrome (HUS), thrombotic thrombocytopenic purpura (TTP), malignant hypertension, drugs or systemic autoimmune diseases or antibody-mediated…
91 Citations
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This is a comprehensive review focusing on the current understanding of viral associated/induced endothelial stimulation and damage that ultimately leads to the development of this life-threatening multisystemic disorder.
Viral-associated thrombotic microangiopathies.
- Medicine, Biology
- 2011
This is a comprehensive review focusing on the current understanding of viral associated/induced endothelial stimulation and damage that ultimately leads to the development of this life-threatening multisystemic disorder.
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- 2020
A case of a 15-year-old Sri Lankan girl diagnosed with atypical hemolytic uremic syndrome complicated with septicemia, hemolytics anemia, acute kidney injury, pulmonary hemorrhage with respiratory failure, and hypertension who had a complete remission following long-term therapeutic plasma exchange is reported.
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- Medicine, BiologyJournal of Nephropathology
- 2019
The distribution of classic TMA findings was not related to etiology in spite of microthrombi having been found mostly in aHUS and secondary etiologies, whereas ischemia was found mainly in STEC-HUS.
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- Medicine, BiologyCureus
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A diagnostically challenging and extremely rare case of a middle-aged Caucasian man who was diagnosed with atypical HUS that was caused by a mutation in complement factor B is reported.
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- Medicine, BiologyThe American journal of case reports
- 2020
A 49-year-old woman with aHUS was presented, which was caused by a novel genetic point mutation of complement factor H gene (p.Gly1110Ala) mimicking secondary HUS with scleroderma, and was successfully treated with mycophenolate mofetil.
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- Medicine, BiologyClinical nephrology
- 2013
The case of a 25-year-old woman with an undefined mixed connective tissue disease who presented 6 weeks post-partum with fever, transient aphasia, thrombocytopenia, hemolytic anemia, and acute kidney injury eventually requiring initiation of hemodialysis is described.
A Case of Thrombotic Microangiopathy Secondary to Hypertensive Emergency
- Medicine, BiologyCureus
- 2022
A 37-year-old African American hypertensive lady presenting with hypertensive emergency and TMA with rapidly progressing renal dysfunction with improvement in her platelet count after her blood pressure was reduced in a controlled manner is reported.
Renal thrombotic microangiopathy in patients with cblC defect: review of an under-recognized entity
- Medicine, BiologyPediatric Nephrology
- 2016
In all patients presenting with unclear intravascular hemolysis, hematuria, and proteinuria, cblC defect should be ruled out by determination of blood/plasma homocysteine levels and/or genetic testing, irrespective of actual renal function and neurological status, to ensure timely diagnosis and treatment.
The Role of Complement Inhibition in Thrombotic Angiopathies and Antiphospholipid Syndrome
- Medicine, BiologyTurkish journal of haematology : official journal of Turkish Society of Haematology
- 2016
In mouse models of APS, activation of the complement is required and interaction of complement (C) 5a with its receptor C5aR leads to aPL-induced inflammation, placental insufficiency, and thrombosis, and anti-C5 antibody and C5 aR antagonist peptides prevent a PL-mediated pregnancy loss and thROMbosis in these experimental models.
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