Thrombotic microangiopathy: new insights

@article{Benz2010ThromboticMN,
  title={Thrombotic microangiopathy: new insights},
  author={Kerstin Benz and Kerstin Amann},
  journal={Current Opinion in Nephrology and Hypertension},
  year={2010},
  volume={19},
  pages={242–247}
}
  • K. Benz, K. Amann
  • Published 1 May 2010
  • Medicine, Biology
  • Current Opinion in Nephrology and Hypertension
Purpose of reviewIn the following study new aspects and insights into the epidemiology, pathogenesis and typical morphology of kidney involvement in thrombotic microangiopathy (TMA) are discussed. TMA comprises a spectrum of microvascular thrombosis syndromes associated with multiple pathogenetic factors, that is, typical and atypical haemolytic uraemic syndrome (HUS), thrombotic thrombocytopenic purpura (TTP), malignant hypertension, drugs or systemic autoimmune diseases or antibody-mediated… 
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  • D. Erkan, J. Salmon
  • Medicine, Biology
    Turkish journal of haematology : official journal of Turkish Society of Haematology
  • 2016
TLDR
In mouse models of APS, activation of the complement is required and interaction of complement (C) 5a with its receptor C5aR leads to aPL-induced inflammation, placental insufficiency, and thrombosis, and anti-C5 antibody and C5 aR antagonist peptides prevent a PL-mediated pregnancy loss and thROMbosis in these experimental models.
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