Thrombotic Complications in PNH

@inproceedings{Sloand2000ThromboticCI,
  title={Thrombotic Complications in PNH},
  author={Elaine M. Sloand and Neal S. Young},
  year={2000}
}
Publisher Summary While no defect in glycosylphosphatidylinositol (GPI)-linked protein definitively shows an increase in clot formation, platelet sensitivity to complement and the absence of cell-associated urokinase plasminogen activator receptor are identified as candidate lesions. Paroxysmal nocturnal hemoglobinuria, a clonal stem cell disorder, is associated with an increased risk of venous thrombosis. Thrombosis is responsible for significant morbidity and is the complication most clearly… CONTINUE READING