Thrombotic Complications in PNH

  title={Thrombotic Complications in PNH},
  author={Elaine M. Sloand and Neal S. Young},
Publisher Summary While no defect in glycosylphosphatidylinositol (GPI)-linked protein definitively shows an increase in clot formation, platelet sensitivity to complement and the absence of cell-associated urokinase plasminogen activator receptor are identified as candidate lesions. Paroxysmal nocturnal hemoglobinuria, a clonal stem cell disorder, is associated with an increased risk of venous thrombosis. Thrombosis is responsible for significant morbidity and is the complication most clearly… CONTINUE READING