Thrombospondins and novel TSR-containing proteins, R-spondins, regulate bone formation and remodeling.

@article{Hankenson2010ThrombospondinsAN,
  title={Thrombospondins and novel TSR-containing proteins, R-spondins, regulate bone formation and remodeling.},
  author={Kurt D. Hankenson and Mariya T. Sweetwyne and Hailu Shitaye and Karen LaShea Posey},
  journal={Current osteoporosis reports},
  year={2010},
  volume={8 2},
  pages={68-76}
}
Thrombospondins (TSPs) are a family of five secreted multimeric matricellular proteins that share homology in the type II and III repeats and carboxy-terminal region. Type I repeats, also known as properdin or thrombospondin repeats (TSRs), are found in TSP1/2, but not TSP3-5. A variety of other secreted proteins contain TSRs, including the novel extracellular molecules, R-spondins. TSP family and many TSR-containing proteins, including R-spondins, are highly expressed in skeletal tissues… CONTINUE READING

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