Thrombospondins Are Astrocyte-Secreted Proteins that Promote CNS Synaptogenesis

  title={Thrombospondins Are Astrocyte-Secreted Proteins that Promote CNS Synaptogenesis},
  author={Karen S. Christopherson and Erik M Ullian and Caleb C. A. Stokes and Christine E. Mullowney and Johannes W Hell and Azin Agah and Jack W Lawler and Deane F Mosher and Paul Bornstein and Ben A Barres},
The establishment of neural circuitry requires vast numbers of synapses to be generated during a specific window of brain development, but it is not known why the developing mammalian brain has a much greater capacity to generate new synapses than the adult brain. Here we report that immature but not mature astrocytes express thrombospondins (TSPs)-1 and -2 and that these TSPs promote CNS synaptogenesis in vitro and in vivo. TSPs induce ultrastructurally normal synapses that are presynaptically… CONTINUE READING
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The functions of thrombospondin - 1 and - 2

  • A. Lim, D. D. Hall, J. W. Hell
  • Curr . Opin . Cell Biol .
  • 2002

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