Thrombospondins Are Astrocyte-Secreted Proteins that Promote CNS Synaptogenesis

  title={Thrombospondins Are Astrocyte-Secreted Proteins that Promote CNS Synaptogenesis},
  author={K. S. Christopherson and E. Ullian and C. Stokes and C. Mullowney and J. Hell and A. Agah and J. Lawler and D. Mosher and P. Bornstein and B. Barres},
  • K. S. Christopherson, E. Ullian, +7 authors B. Barres
  • Published 2005
  • Medicine, Biology
  • Cell
  • The establishment of neural circuitry requires vast numbers of synapses to be generated during a specific window of brain development, but it is not known why the developing mammalian brain has a much greater capacity to generate new synapses than the adult brain. Here we report that immature but not mature astrocytes express thrombospondins (TSPs)-1 and -2 and that these TSPs promote CNS synaptogenesis in vitro and in vivo. TSPs induce ultrastructurally normal synapses that are presynaptically… CONTINUE READING
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