Thrombospondins Are Astrocyte-Secreted Proteins that Promote CNS Synaptogenesis

  title={Thrombospondins Are Astrocyte-Secreted Proteins that Promote CNS Synaptogenesis},
  author={K. S. Christopherson and E. Ullian and C. Stokes and C. Mullowney and J. Hell and A. Agah and J. Lawler and D. Mosher and P. Bornstein and B. Barres},
  • K. S. Christopherson, E. Ullian, +7 authors B. Barres
  • Published 2005
  • Medicine, Biology
  • Cell
  • The establishment of neural circuitry requires vast numbers of synapses to be generated during a specific window of brain development, but it is not known why the developing mammalian brain has a much greater capacity to generate new synapses than the adult brain. Here we report that immature but not mature astrocytes express thrombospondins (TSPs)-1 and -2 and that these TSPs promote CNS synaptogenesis in vitro and in vivo. TSPs induce ultrastructurally normal synapses that are presynaptically… CONTINUE READING

    Figures and Topics from this paper.

    Explore Further: Topics Discussed in This Paper

    Gabapentin Receptor α2δ-1 Is a Neuronal Thrombospondin Receptor Responsible for Excitatory CNS Synaptogenesis
    • 519
    • PDF
    Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC
    • 301
    • PDF
    Control of CNS Synapse Development by γ-Protocadherin-Mediated Astrocyte–Neuron Contact
    • 128
    • Highly Influenced
    • PDF
    The role of astrocyte-secreted matricellular proteins in central nervous system development and function
    • 74
    • Highly Influenced
    • PDF


    Publications referenced by this paper.
    CNS synaptogenesis promoted by glia-derived cholesterol.
    • 1,321
    • Highly Influential
    Role for glia in synaptogenesis
    • 366
    • PDF
    Control of synapse number by glia.
    • 1,154
    FGF22 and Its Close Relatives Are Presynaptic Organizing Molecules in the Mammalian Brain
    • 250
    • Highly Influential
    Synaptic efficacy enhanced by glial cells in vitro.
    • 706
    • PDF