Thrombospondin mediates the cytoadherence of Plasmodium falciparum-infected red cells to vascular endothelium in shear flow conditions.

@article{Rock1988ThrombospondinMT,
  title={Thrombospondin mediates the cytoadherence of Plasmodium falciparum-infected red cells to vascular endothelium in shear flow conditions.},
  author={Erich Rock and Eugene F. Jr. Roth and R. R. Rojas-Corona and James A. Sherwood and Ronald L. Nagel and Russell John Howard and Dhananjay K. Kaul},
  journal={Blood},
  year={1988},
  volume={71 1},
  pages={
          71-5
        }
}
Cerebral malaria is thought to involve specific attachment of Plasmodium falciparum-infected knobby red cells to venular endothelium. The nature of surface ligands on host endothelial cells that may mediate cytoadherence is poorly understood. We have investigated the effects of soluble thrombospondin, rabbit antiserum raised against thrombospondin, and human immune serum on cytoadherence of parasitized erythrocytes in ex vivo mesocecum vasculature. Preincubation of infected red cells with… CONTINUE READING

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