Thrombospondin-induced adhesion of human platelets.

  title={Thrombospondin-induced adhesion of human platelets.},
  author={George P. Tuszynski and Maria Anna Kowalska},
  journal={The Journal of clinical investigation},
  volume={87 4},
Washed human unactivated platelets attached and spread on thrombospondin (TSP)-coated microtiter plates. Platelet adhesion was promoted by divalent cations Mn2+, Mg2+, and Ca2+ as compared to buffer having all divalent cations complexed with EDTA. TSP-dependent adhesion was inhibited by anti-TSP fab fragments, an anti-TSP monoclonal antibody, an RGD-containing peptide, complex-specific anti-glycoprotein (GP)IIb-IIIa monoclonal antibodies (A2A9 or AP-2) and anti-VLA-2 monoclonal antibodies (6F1… CONTINUE READING
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