Thrombospondin exerts an antiangiogenic effect on cord formation by endothelial cells in vitro.

@article{IruelaArispe1991ThrombospondinEA,
  title={Thrombospondin exerts an antiangiogenic effect on cord formation by endothelial cells in vitro.},
  author={M Luisa Iruela-Arispe and Paul Bornstein and Harvey Sage},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 11},
  pages={5026-30}
}
The response of endothelial cells to angiogenic stimuli has been shown to be influenced by the extracellular microenvironment. We tested whether thrombospondin, an extracellular matrix protein, modulated the spontaneous formation of cords by endothelial cells in vitro. Despite continued proliferation, a decrease in secreted thrombospondin was detected in cord-containing, as compared with subconfluent, cultures of both aortic and microvascular endothelial cells. Consistent with this trend, mRNA… CONTINUE READING