Thrombospondin-4 regulates fibrosis and remodeling of the myocardium in response to pressure overload.

@article{Frolova2012Thrombospondin4RF,
  title={Thrombospondin-4 regulates fibrosis and remodeling of the myocardium in response to pressure overload.},
  author={Ella G. Frolova and Nikolai A Sopko and Lauren Blech and Zoran B Popovi{\'c} and Jianbo Li and Amit Vasanji and Carla Drumm and Irene Krukovets and Mukesh K Jain and Marc S. Penn and Edward F Plow and Olga I. Stenina},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2012},
  volume={26 6},
  pages={
          2363-73
        }
}
Thrombospondin-4 (TSP-4) expression increases dramatically in hypertrophic and failing hearts in rodent models and in humans. The aim of this study was to address the function of TSP-4 in the heart. TSP-4-knockout (Thbs4(-/-)) and wild-type (WT) mice were subjected to transverse aortic constriction (TAC) to increase left ventricle load. After 2 wk, Thbs4(-/-) mice had a significantly higher heart weight/body weight ratio than WT mice. The additional increase in the heart weight in TAC Thbs4… CONTINUE READING
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