Thrombospondin-4 controls matrix assembly during development and repair of myotendinous junctions

@inproceedings{Subramanian2014Thrombospondin4CM,
  title={Thrombospondin-4 controls matrix assembly during development and repair of myotendinous junctions},
  author={Arul Subramanian and Thomas F Schilling},
  booktitle={eLife},
  year={2014}
}
Tendons are extracellular matrix (ECM)-rich structures that mediate muscle attachments with the skeleton, but surprisingly little is known about molecular mechanisms of attachment. Individual myofibers and tenocytes in Drosophila interact through integrin (Itg) ligands such as Thrombospondin (Tsp), while vertebrate muscles attach to complex ECM fibrils embedded with tenocytes. We show for the first time that a vertebrate thrombospondin, Tsp4b, is essential for muscle attachment and ECM assembly… CONTINUE READING
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