Thrombospondin 2 promotes tumor metastasis by inducing matrix metalloproteinase-13 production in lung cancer cells.

@article{Liu2018Thrombospondin2P,
  title={Thrombospondin 2 promotes tumor metastasis by inducing matrix metalloproteinase-13 production in lung cancer cells.},
  author={Ju-Fang Liu and Chiang-Wen Lee and Ming-Horng Tsai and Chih-Hsin Tang and Po-Chun Chen and Leong Jern Lin and Chih-Yang Lin and Chih-Hao Lu and Yue Lin and Shih-Hsing Yang and Chia-Chia Chao},
  journal={Biochemical pharmacology},
  year={2018},
  volume={155},
  pages={
          537-546
        }
}
Thrombospondin (TSP)-2, a matricellular glycoprotein of the TSP family, regulates multiple biological functions, including proliferation, angiogenesis, cell adhesion, and extracellular matrix (ECM) modeling. The clinical relevance of TSP-2 has been explored in many different cancers. TSP-2 expression levels vary between different cancer types, and their role in tumor progression remains controversial. Although previous studies have reported higher serum TSP-2 levels in patients with non-small… CONTINUE READING
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SHOWING 1-10 OF 70 REFERENCES

Z

C. B. Little, A. Barai, D. Burkhardt, S. M. Smith, A. J. Fosang
  • Werb, et al., Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development, Arthritis Rheum. 60
  • 2009
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

New functions for the matrix metalloproteinases in cancer progression

Mikala Egeblad, Zena Werb
  • Nature Reviews Cancer
  • 2002
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL

M

T. Chijiwa, Y. Abe, Y. Inoue, H. Matsumoto, K. Kawai
  • Matsuyama, et al., Cancerous, but not stromal, thrombospondin-2 contributes prognosis in pulmonary adenocarcinoma, Oncol. Rep. 22
  • 2009
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

A

P. J. Davis, H. Y. Lin, T. Sudha, M. Yalcin, H. Y. Tang
  • Hercbergs, et al., Nanotetrac targets integrin alphavbeta3 on tumor cells to disorder cell defense pathways and block angiogenesis, Onco Targets Ther. 7 (2014) 1619–1624. J.-F. Liu et al. Biochemical Pharmacology 155
  • 2018
VIEW 1 EXCERPT

M

F. Cayrol, M. C. Diaz Flaque, T. Fernando, S. N. Yang, H. A. Sterle
  • Bolontrade, et al., Integrin alphavbeta3 acting as membrane receptor for thyroid hormones mediates angiogenesis in malignant T cells, Blood 125
  • 2015

A

A. Radziwon-Balicka, M. J. Santos-Martinez, J. J. Corbalan, S. O'Sullivan
  • Treumann, J.F. Gilmer, et al., Mechanisms of platelet-stimulated colon cancer invasion: role of clusterin and thrombospondin 1 in regulation of the P38MAPK- MMP-9 pathway, Carcinogenesis 35
  • 2014

C

A. Jayachandran, M. Anaka, P. Prithviraj
  • Hudson, S.J. McKeown, P.H. Lo, et al., Thrombospondin 1 promotes an aggressive phenotype through epithelial-to-mesenchymal transition in human melanoma, Oncotarget 5
  • 2014
VIEW 2 EXCERPTS

Current understanding of the thrombospondin-1 interactome.

  • Matrix biology : journal of the International Society for Matrix Biology
  • 2014
VIEW 1 EXCERPT