Thrombospondin 2-null mice display an altered brain foreign body response to polyvinyl alcohol sponge implants.

@article{Tian2009Thrombospondin2M,
  title={Thrombospondin 2-null mice display an altered brain foreign body response to polyvinyl alcohol sponge implants.},
  author={Weiming Tian and Themis R Kyriakides},
  journal={Biomedical materials},
  year={2009},
  volume={4 1},
  pages={015010}
}
Thrombospondin (TSP)-2 is a matricellular protein that participates in the processes of tissue repair and the foreign body response. In addition, TSP2 has been shown to influence synaptogenesis and recovery of the brain following stroke. In the present study we investigated the response following the implantation of polyvinyl alcohol (PVA) sponges in the brain. PVA sponges were implanted into the brain cortex of wild type and TSP2-null mice for a period of 4 and 8 weeks and the response was… CONTINUE READING
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