Thrombospondin 2, a matricellular protein with diverse functions.

  title={Thrombospondin 2, a matricellular protein with diverse functions.},
  author={Paul Bornstein and Lucas C. Armstrong and Kurt D. Hankenson and Themis R Kyriakides and Zhongzhou Yang},
  journal={Matrix biology : journal of the International Society for Matrix Biology},
  volume={19 7},
Thrombospondin (TSP) 2 is a close relative of TSP1 but differs in its temporal and spatial distribution in the mouse. This difference in expression undoubtedly reflects the marked disparity in the DNA sequences of the promoters in the genes encoding the two proteins. The synthesis of TSP2 occurs primarily in connective tissues of the developing and growing mouse. In the adult animal the protein is again produced in response to tissue injury and in association with the growth of tumors. Despite… CONTINUE READING