Thrombospondin-1 supports blood pressure by limiting eNOS activation and endothelial-dependent vasorelaxation.

  title={Thrombospondin-1 supports blood pressure by limiting eNOS activation and endothelial-dependent vasorelaxation.},
  author={Eileen M. Bauer and Yan Qin and Thomas W Miller and Russell W. Bandle and G{\'a}bor Cs{\'a}nyi and Patrick J Pagano and Philip M. Bauer and J{\"u}rgen B. Schnermann and David D. Roberts and Jeff S. Isenberg},
  journal={Cardiovascular research},
  volume={88 3},
AIMS Thrombospondin-1 (TSP1), via its necessary receptor CD47, inhibits nitric oxide (NO)-stimulated soluble guanylate cyclase activation in vascular smooth muscle cells, and TSP1-null mice have increased shear-dependent blood flow compared with wild-type mice. Yet, the endothelial basement membrane should in theory function as a barrier to diffusion of soluble TSP1 into the arterial smooth muscle cell layer. These findings suggested that endothelial-dependent differences in blood flow in TSP1… CONTINUE READING
Highly Cited
This paper has 84 citations. REVIEW CITATIONS


Publications citing this paper.
Showing 1-10 of 49 extracted citations

Endothelial nitric oxide synthase controls the expression of the angiogenesis inhibitor thrombospondin 2.

Proceedings of the National Academy of Sciences of the United States of America • 2011
View 10 Excerpts
Highly Influenced

Leukocyte surface antigen CD 47

Soto Pantoja, Reinhard David, Kaur, Sukhbir, York E. Miller
View 7 Excerpts
Highly Influenced

Physiological levels of thrombospondin-1 decrease NO-dependent vasodilation in coronary microvessels from aged rats.

American journal of physiology. Heart and circulatory physiology • 2016
View 5 Excerpts
Highly Influenced

84 Citations

Citations per Year
Semantic Scholar estimates that this publication has 84 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-10 of 45 references

Thrombospondin-1 and CD47 regulate blood pressure and cardiac responses to vasoactive stress.

Matrix biology : journal of the International Society for Matrix Biology • 2009
View 2 Excerpts