Thrombospondin-1 supports blood pressure by limiting eNOS activation and endothelial-dependent vasorelaxation.

@article{Bauer2010Thrombospondin1SB,
  title={Thrombospondin-1 supports blood pressure by limiting eNOS activation and endothelial-dependent vasorelaxation.},
  author={Eileen M. Bauer and Yan Qin and Thomas W Miller and Russell W. Bandle and G{\'a}bor Cs{\'a}nyi and Patrick J Pagano and Philip M. Bauer and J{\"u}rgen B. Schnermann and David D. Roberts and Jeff S. Isenberg},
  journal={Cardiovascular research},
  year={2010},
  volume={88 3},
  pages={
          471-81
        }
}
AIMS Thrombospondin-1 (TSP1), via its necessary receptor CD47, inhibits nitric oxide (NO)-stimulated soluble guanylate cyclase activation in vascular smooth muscle cells, and TSP1-null mice have increased shear-dependent blood flow compared with wild-type mice. Yet, the endothelial basement membrane should in theory function as a barrier to diffusion of soluble TSP1 into the arterial smooth muscle cell layer. These findings suggested that endothelial-dependent differences in blood flow in TSP1… CONTINUE READING
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Thrombospondin-1 and CD47 regulate blood pressure and cardiac responses to vasoactive stress.

Matrix biology : journal of the International Society for Matrix Biology • 2009
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